Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 3521578..3522214 | Replicon | chromosome |
| Accession | NC_019896 | ||
| Organism | Bacillus subtilis subsp. subtilis str. BSP1 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | A7A1_RS18160 | Protein ID | WP_003156187.1 |
| Coordinates | 3521578..3521928 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G4NU32 |
| Locus tag | A7A1_RS18165 | Protein ID | WP_003225183.1 |
| Coordinates | 3521933..3522214 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A1_RS18120 | 3516622..3517221 | - | 600 | WP_003246608.1 | phosphoserine phosphatase RsbX | - |
| A7A1_RS18125 | 3517221..3518009 | - | 789 | WP_044052630.1 | RNA polymerase sigma factor SigB | - |
| A7A1_RS18130 | 3517975..3518457 | - | 483 | WP_003234299.1 | anti-sigma B factor RsbW | - |
| A7A1_RS18135 | 3518454..3518783 | - | 330 | WP_003234298.1 | anti-sigma factor antagonist RsbV | - |
| A7A1_RS18140 | 3518845..3519852 | - | 1008 | WP_015252763.1 | phosphoserine phosphatase RsbU | - |
| A7A1_RS18145 | 3519864..3520264 | - | 401 | Protein_3527 | serine/threonine-protein kinase RsbT | - |
| A7A1_RS18150 | 3520268..3520633 | - | 366 | WP_003225190.1 | RsbT antagonist protein RsbS | - |
| A7A1_RS18155 | 3520638..3521462 | - | 825 | WP_015252765.1 | RsbT co-antagonist protein RsbRA | - |
| A7A1_RS18160 | 3521578..3521928 | - | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| A7A1_RS18165 | 3521933..3522214 | - | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| A7A1_RS18170 | 3522330..3523499 | - | 1170 | WP_015252766.1 | alanine racemase | - |
| A7A1_RS18175 | 3523614..3524630 | - | 1017 | WP_080019556.1 | outer membrane lipoprotein carrier protein LolA | - |
| A7A1_RS18180 | 3524796..3525161 | - | 366 | WP_015252768.1 | holo-ACP synthase | - |
| A7A1_RS18185 | 3525256..3525855 | + | 600 | WP_015252769.1 | rhomboid family intramembrane serine protease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T28634 WP_003156187.1 NC_019896:c3521928-3521578 [Bacillus subtilis subsp. subtilis str. BSP1]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T28634 NC_019896:c3521928-3521578 [Bacillus subtilis subsp. subtilis str. BSP1]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10546.92 Da Isoelectric Point: 6.4708
>AT28634 WP_003225183.1 NC_019896:c3522214-3521933 [Bacillus subtilis subsp. subtilis str. BSP1]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT28634 NC_019896:c3522214-3521933 [Bacillus subtilis subsp. subtilis str. BSP1]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|