Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1835991..1836581 Replicon chromosome
Accession NZ_LR130544
Organism Klebsiella variicola strain 03-311-0071 isolate 03-311-0071

Toxin (Protein)


Gene name pemK Uniprot ID A0A1F2LYA2
Locus tag EW041_RS09015 Protein ID WP_008804165.1
Coordinates 1836249..1836581 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A1F2LZQ3
Locus tag EW041_RS09010 Protein ID WP_012541132.1
Coordinates 1835991..1836248 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW041_RS08985 1831601..1832176 + 576 WP_043875014.1 hypothetical protein -
EW041_RS08990 1832353..1833189 + 837 WP_104458716.1 alpha/beta hydrolase -
EW041_RS08995 1833395..1834366 + 972 WP_072124611.1 sensor domain-containing diguanylate cyclase -
EW041_RS09000 1834363..1835463 - 1101 WP_064160538.1 phosphotransferase -
EW041_RS09010 1835991..1836248 + 258 WP_012541132.1 antitoxin Antitoxin
EW041_RS09015 1836249..1836581 + 333 WP_008804165.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EW041_RS09025 1836904..1838340 + 1437 WP_042948427.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
EW041_RS09035 1838666..1838815 - 150 Protein_1729 antitoxin -
EW041_RS09040 1839019..1839321 - 303 WP_032700907.1 XRE family transcriptional regulator -
EW041_RS09045 1839326..1839679 - 354 WP_008804168.1 type II toxin-antitoxin system RelE/ParE family toxin -
EW041_RS09050 1839883..1841364 + 1482 WP_008804169.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11867.71 Da        Isoelectric Point: 10.1839

>T286336 WP_008804165.1 NZ_LR130544:1836249-1836581 [Klebsiella variicola]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9420.91 Da        Isoelectric Point: 4.4915

>AT286336 WP_012541132.1 NZ_LR130544:1835991-1836248 [Klebsiella variicola]
MYKTRLKKVGGSIMLAVPPAVLKALELSTDSEVGMTIDNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2LYA2

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZQ3

References