Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4742604..4743296 Replicon chromosome
Accession NZ_LR130543
Organism Klebsiella variicola strain 04153260899A isolate 04153260899A

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag EW039_RS23380 Protein ID WP_080851713.1
Coordinates 4742604..4742945 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag EW039_RS23385 Protein ID WP_040189932.1
Coordinates 4742970..4743296 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW039_RS23365 4738345..4740141 - 1797 WP_129678768.1 hypothetical protein -
EW039_RS23370 4740143..4741375 - 1233 WP_197724857.1 metallophosphoesterase -
EW039_RS23375 4741655..4742488 - 834 WP_080851711.1 DUF4942 domain-containing protein -
EW039_RS23380 4742604..4742945 - 342 WP_080851713.1 TA system toxin CbtA family protein Toxin
EW039_RS23385 4742970..4743296 - 327 WP_040189932.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EW039_RS23390 4743310..4743786 - 477 WP_080851715.1 DNA repair protein RadC -
EW039_RS23395 4743797..4744243 - 447 WP_080851716.1 antirestriction protein -
EW039_RS23400 4744466..4745155 - 690 WP_080851718.1 hypothetical protein -
EW039_RS23410 4745720..4746610 - 891 WP_080851722.1 50S ribosome-binding GTPase -
EW039_RS23415 4746693..4747781 - 1089 WP_129678769.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4728145..4759127 30982


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12746.63 Da        Isoelectric Point: 7.8846

>T286330 WP_080851713.1 NZ_LR130543:c4742945-4742604 [Klebsiella variicola]
MKTIPATTQRAAKSCPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQVTGLVRQSPHPSIR

Download         Length: 342 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12333.06 Da        Isoelectric Point: 6.9560

>AT286330 WP_040189932.1 NZ_LR130543:c4743296-4742970 [Klebsiella variicola]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFVDAECQKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References