Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2725073..2726661 Replicon chromosome
Accession NZ_LR130543
Organism Klebsiella variicola strain 04153260899A isolate 04153260899A

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EW039_RS13585 Protein ID WP_096834627.1
Coordinates 2725073..2726395 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2V3KHJ7
Locus tag EW039_RS13590 Protein ID WP_038422544.1
Coordinates 2726395..2726661 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW039_RS13570 2720138..2722639 + 2502 WP_080928616.1 fimbrial biogenesis outer membrane usher protein -
EW039_RS13575 2722627..2723631 + 1005 WP_087498799.1 type 1 fimbrial protein -
EW039_RS13580 2723764..2725056 + 1293 WP_012968243.1 glycoside hydrolase family 10 protein -
EW039_RS13585 2725073..2726395 - 1323 WP_096834627.1 type II toxin-antitoxin system HipA family toxin Toxin
EW039_RS13590 2726395..2726661 - 267 WP_038422544.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EW039_RS13595 2727169..2727495 - 327 WP_008804921.1 hydroxyisourate hydrolase -
EW039_RS13600 2727492..2727992 - 501 WP_008804922.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
EW039_RS13605 2727970..2729349 - 1380 WP_012968246.1 purine permease -
EW039_RS13610 2729695..2730849 + 1155 WP_008804924.1 FAD-dependent urate hydroxylase HpxO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48881.24 Da        Isoelectric Point: 7.9109

>T286327 WP_096834627.1 NZ_LR130543:c2726395-2725073 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSAHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9923.30 Da        Isoelectric Point: 8.5912

>AT286327 WP_038422544.1 NZ_LR130543:c2726661-2726395 [Klebsiella variicola]
MTSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2V3KHJ7

References