Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 762701..763358 Replicon chromosome
Accession NZ_LR130543
Organism Klebsiella variicola strain 04153260899A isolate 04153260899A

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag EW039_RS03825 Protein ID WP_002916310.1
Coordinates 762948..763358 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag EW039_RS03820 Protein ID WP_002916312.1
Coordinates 762701..762967 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW039_RS03795 757746..759179 - 1434 WP_012540589.1 6-phospho-beta-glucosidase BglA -
EW039_RS03800 759299..760027 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
EW039_RS03805 760078..760389 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
EW039_RS03810 760553..761212 + 660 WP_008806429.1 hemolysin III family protein -
EW039_RS03815 761472..762455 - 984 WP_008806428.1 tRNA-modifying protein YgfZ -
EW039_RS03820 762701..762967 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
EW039_RS03825 762948..763358 + 411 WP_002916310.1 protein YgfX Toxin
EW039_RS03830 763365..763886 - 522 WP_008806427.1 flavodoxin FldB -
EW039_RS03835 763987..764883 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
EW039_RS03840 764906..765619 + 714 WP_087653414.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EW039_RS03845 765625..767358 + 1734 WP_087731373.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T286321 WP_002916310.1 NZ_LR130543:762948-763358 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT286321 WP_002916312.1 NZ_LR130543:762701-762967 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References