Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 274956..275587 Replicon chromosome
Accession NZ_LR130543
Organism Klebsiella variicola strain 04153260899A isolate 04153260899A

Toxin (Protein)


Gene name hicA Uniprot ID A0A1F2M5P8
Locus tag EW039_RS01250 Protein ID WP_023323362.1
Coordinates 274956..275231 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID R4YIG2
Locus tag EW039_RS01255 Protein ID WP_004181489.1
Coordinates 275228..275587 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW039_RS01230 270192..270527 + 336 WP_002921203.1 universal stress protein UspB -
EW039_RS01235 270587..272083 - 1497 WP_008806938.1 inorganic phosphate transporter PitA -
EW039_RS01240 272313..273506 + 1194 WP_012967106.1 NAD(P)/FAD-dependent oxidoreductase -
EW039_RS01245 273546..274559 - 1014 WP_023323363.1 magnesium transporter -
EW039_RS01250 274956..275231 + 276 WP_023323362.1 type II toxin-antitoxin system HicA family toxin Toxin
EW039_RS01255 275228..275587 + 360 WP_004181489.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EW039_RS01260 275615..276016 - 402 WP_023323361.1 nickel-responsive transcriptional regulator NikR -
EW039_RS01265 276004..276795 - 792 WP_012540373.1 nickel import ATP-binding protein NikE -
EW039_RS01270 276792..277556 - 765 WP_023323360.1 nickel import ATP-binding protein NikD -
EW039_RS01275 277556..278389 - 834 WP_012967107.1 nickel ABC transporter permease subunit NikC -
EW039_RS01280 278386..279330 - 945 WP_023323359.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10260.86 Da        Isoelectric Point: 9.9665

>T286318 WP_023323362.1 NZ_LR130543:274956-275231 [Klebsiella variicola]
MEQQVLSLRNKQHHTLEQLFKIPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13313.02 Da        Isoelectric Point: 4.4605

>AT286318 WP_004181489.1 NZ_LR130543:275228-275587 [Klebsiella variicola]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCHEAGIEPYAHPEKMKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2M5P8

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2M5Q1

References