286310

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2726954..2728542 Replicon chromosome
Accession NZ_LR130541
Organism Klebsiella pneumoniae strain AJ218 isolate AJ218

Toxin (Protein)


Gene name hipA Uniprot ID W9B834
Locus tag EW045_RS13680 Protein ID WP_016529318.1
Coordinates 2726954..2728276 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag EW045_RS13685 Protein ID WP_002904790.1
Coordinates 2728276..2728542 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW045_RS13660 2722010..2724511 + 2502 WP_048269116.1 fimbrial biogenesis outer membrane usher protein -
EW045_RS13665 2724499..2725503 + 1005 WP_032421320.1 type 1 fimbrial protein -
EW045_RS13675 2725645..2726937 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
EW045_RS13680 2726954..2728276 - 1323 WP_016529318.1 type II toxin-antitoxin system HipA family toxin Toxin
EW045_RS13685 2728276..2728542 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EW045_RS13690 2728808..2729134 - 327 WP_002904788.1 hydroxyisourate hydrolase -
EW045_RS13695 2729131..2729631 - 501 WP_032434523.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
EW045_RS13700 2729609..2730988 - 1380 WP_002904785.1 purine permease -
EW045_RS13705 2731334..2732488 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
EW045_RS13710 2732469..2733392 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5366

>T286310 WP_016529318.1 NZ_LR130541:c2728276-2726954 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT286310 WP_002904790.1 NZ_LR130541:c2728542-2728276 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9B834

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References