286302

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 89149..89816 Replicon chromosome
Accession NZ_LR130541
Organism Klebsiella pneumoniae strain AJ218 isolate AJ218

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag EW045_RS00460 Protein ID WP_048269603.1
Coordinates 89149..89469 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID E1IS67
Locus tag EW045_RS00465 Protein ID WP_000052843.1
Coordinates 89490..89816 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW045_RS00430 84803..85852 - 1050 WP_002922967.1 NAD(P)-dependent alcohol dehydrogenase -
EW045_RS00435 86225..86923 + 699 WP_129718166.1 winged helix-turn-helix transcriptional regulator -
EW045_RS00440 86974..87264 - 291 WP_002922965.1 antibiotic biosynthesis monooxygenase -
EW045_RS00445 87266..88273 - 1008 WP_002922964.1 zinc-binding alcohol dehydrogenase family protein -
EW045_RS00450 88386..88853 - 468 WP_002922963.1 DUF3237 domain-containing protein -
EW045_RS00460 89149..89469 - 321 WP_048269603.1 TA system toxin CbtA family protein Toxin
EW045_RS00465 89490..89816 - 327 WP_000052843.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EW045_RS00470 89829..90299 - 471 WP_001275770.1 DNA repair protein RadC -
EW045_RS00475 90368..91189 - 822 WP_048269602.1 DUF945 domain-containing protein -
EW045_RS00480 91282..92292 - 1011 WP_001348677.1 hypothetical protein -
EW045_RS00485 92354..93043 - 690 WP_015703837.1 WYL domain-containing protein -
EW045_RS00490 93235..94128 - 894 WP_048269601.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-98)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12094.90 Da        Isoelectric Point: 5.5873

>T286302 WP_048269603.1 NZ_LR130541:c89469-89149 [Klebsiella pneumoniae]
MKTQPATTPQAAKPCLSPLAVWQMLLTSLLDQHYGLTLNDTPFSDETIIQKHIEAGITLADAVNFLVERYELVRIDQKGF
SVQDQEPWLTSMDVHRARFKLNVERL

Download         Length: 321 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12305.01 Da        Isoelectric Point: 6.3620

>AT286302 WP_000052843.1 NZ_LR130541:c89816-89490 [Klebsiella pneumoniae]
MSLIPAHEWGLQREIVPRFGARLVQEGNRLHYLADRANLMGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHHHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A345ENE4

References