Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5102335..5104016 Replicon chromosome
Accession NZ_LR130539
Organism Klebsiella variicola strain AJ055 isolate AJ055

Toxin (Protein)


Gene name mosT Uniprot ID A0A7H4S924
Locus tag EW050_RS25095 Protein ID WP_012969143.1
Coordinates 5102335..5103252 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A0B7GCX3
Locus tag EW050_RS25100 Protein ID WP_008807257.1
Coordinates 5103258..5104016 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW050_RS25075 5097641..5099161 + 1521 WP_064324014.1 sugar ABC transporter ATP-binding protein -
EW050_RS25080 5099158..5100156 + 999 WP_023296904.1 ribose ABC transporter permease -
EW050_RS25085 5100187..5101128 + 942 WP_012543155.1 ABC transporter substrate-binding protein -
EW050_RS25090 5101203..5102210 + 1008 WP_046878672.1 carbohydrate kinase family protein -
EW050_RS25095 5102335..5103252 - 918 WP_012969143.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
EW050_RS25100 5103258..5104016 - 759 WP_008807257.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
EW050_RS25105 5104101..5104829 - 729 WP_008807258.1 response regulator transcription factor -
EW050_RS25110 5105102..5107249 + 2148 WP_077598908.1 formate dehydrogenase subunit alpha -
EW050_RS25115 5107779..5108465 + 687 WP_008807260.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34721.11 Da        Isoelectric Point: 5.4707

>T286298 WP_012969143.1 NZ_LR130539:c5103252-5102335 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28653.01 Da        Isoelectric Point: 10.1988

>AT286298 WP_008807257.1 NZ_LR130539:c5104016-5103258 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4S924

Antitoxin

Source ID Structure
AlphaFold DB A0A0B7GCX3

References