Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4943282..4943798 Replicon chromosome
Accession NZ_LR130539
Organism Klebsiella variicola strain AJ055 isolate AJ055

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag EW050_RS24280 Protein ID WP_002886902.1
Coordinates 4943282..4943566 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag EW050_RS24285 Protein ID WP_002886901.1
Coordinates 4943556..4943798 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW050_RS24265 4938385..4940040 + 1656 WP_008807132.1 alpha,alpha-phosphotrehalase -
EW050_RS24270 4940426..4942564 + 2139 WP_023339462.1 anaerobic ribonucleoside-triphosphate reductase -
EW050_RS24275 4942814..4943278 + 465 WP_048331327.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
EW050_RS24280 4943282..4943566 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EW050_RS24285 4943556..4943798 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EW050_RS24290 4943876..4945786 - 1911 WP_032731805.1 BglG family transcription antiterminator -
EW050_RS24295 4945809..4946963 - 1155 WP_049164103.1 lactonase family protein -
EW050_RS24300 4947089..4947829 - 741 WP_022065398.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T286297 WP_002886902.1 NZ_LR130539:c4943566-4943282 [Klebsiella variicola]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT286297 WP_002886901.1 NZ_LR130539:c4943798-4943556 [Klebsiella variicola]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References