Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 805960..806617 Replicon chromosome
Accession NZ_LR130539
Organism Klebsiella variicola strain AJ055 isolate AJ055

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag EW050_RS04020 Protein ID WP_002916310.1
Coordinates 806207..806617 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag EW050_RS04015 Protein ID WP_002916312.1
Coordinates 805960..806226 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW050_RS03990 801109..802542 - 1434 WP_110184899.1 6-phospho-beta-glucosidase BglA -
EW050_RS03995 802662..803390 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
EW050_RS04000 803441..803752 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
EW050_RS04005 803916..804575 + 660 WP_008806429.1 hemolysin III family protein -
EW050_RS04010 804731..805714 - 984 WP_032740987.1 tRNA-modifying protein YgfZ -
EW050_RS04015 805960..806226 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
EW050_RS04020 806207..806617 + 411 WP_002916310.1 protein YgfX Toxin
EW050_RS04025 806624..807145 - 522 WP_008806427.1 flavodoxin FldB -
EW050_RS04030 807246..808142 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
EW050_RS04035 808165..808878 + 714 WP_012540593.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EW050_RS04040 808884..810617 + 1734 WP_032736401.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T286288 WP_002916310.1 NZ_LR130539:806207-806617 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT286288 WP_002916312.1 NZ_LR130539:805960-806226 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References