Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1766457..1767047 Replicon chromosome
Accession NZ_LR130538
Organism Klebsiella variicola strain AJ292 isolate AJ292

Toxin (Protein)


Gene name pemK Uniprot ID A0A1F2LYA2
Locus tag EW044_RS08685 Protein ID WP_008804165.1
Coordinates 1766715..1767047 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag EW044_RS08680 Protein ID WP_129675475.1
Coordinates 1766457..1766714 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW044_RS08670 1763947..1765896 - 1950 WP_101825858.1 hypothetical protein -
EW044_RS08680 1766457..1766714 + 258 WP_129675475.1 antitoxin Antitoxin
EW044_RS08685 1766715..1767047 + 333 WP_008804165.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EW044_RS08695 1767371..1768807 + 1437 WP_016161429.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
EW044_RS08705 1769180..1770634 - 1455 WP_008804170.1 AMP nucleosidase -
EW044_RS08710 1770765..1771010 - 246 WP_008804171.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1758863..1767047 8184


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11867.71 Da        Isoelectric Point: 10.1839

>T286276 WP_008804165.1 NZ_LR130538:1766715-1767047 [Klebsiella variicola]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9481.07 Da        Isoelectric Point: 5.1019

>AT286276 WP_129675475.1 NZ_LR130538:1766457-1766714 [Klebsiella variicola]
MYKTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDRKWIDAPAM
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2LYA2

Antitoxin

Source ID Structure

References