Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 775909..776566 Replicon chromosome
Accession NZ_LR130538
Organism Klebsiella variicola strain AJ292 isolate AJ292

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag EW044_RS03905 Protein ID WP_002916310.1
Coordinates 776156..776566 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag EW044_RS03900 Protein ID WP_002916312.1
Coordinates 775909..776175 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW044_RS03875 771110..772543 - 1434 WP_012967244.1 6-phospho-beta-glucosidase BglA -
EW044_RS03880 772663..773391 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
EW044_RS03885 773442..773753 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
EW044_RS03890 773917..774576 + 660 WP_008806429.1 hemolysin III family protein -
EW044_RS03895 774680..775663 - 984 WP_012967246.1 tRNA-modifying protein YgfZ -
EW044_RS03900 775909..776175 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
EW044_RS03905 776156..776566 + 411 WP_002916310.1 protein YgfX Toxin
EW044_RS03910 776573..777094 - 522 WP_008806427.1 flavodoxin FldB -
EW044_RS03915 777195..778091 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
EW044_RS03920 778114..778827 + 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EW044_RS03925 778833..780566 + 1734 WP_008806424.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T286275 WP_002916310.1 NZ_LR130538:776156-776566 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT286275 WP_002916312.1 NZ_LR130538:775909-776175 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References