Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 768643..769328 Replicon plasmid pRmeGR4c
Accession NC_019848
Organism Sinorhizobium meliloti GR4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C770_RS39095 Protein ID WP_017277131.1
Coordinates 768909..769328 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C770_RS39090 Protein ID WP_015242241.1
Coordinates 768643..768912 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C770_RS39075 764163..765032 - 870 WP_080991260.1 aldo/keto reductase family oxidoreductase -
C770_RS39080 765149..766072 + 924 WP_015242238.1 LysR family transcriptional regulator -
C770_RS39085 767048..767923 + 876 WP_015242240.1 LysR family transcriptional regulator -
C770_RS51545 768035..768533 - 499 Protein_713 hypothetical protein -
C770_RS39090 768643..768912 + 270 WP_015242241.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C770_RS39095 768909..769328 + 420 WP_017277131.1 type II toxin-antitoxin system VapC family toxin Toxin
C770_RS39100 769577..770031 + 455 Protein_716 IS630-like element ISRm2011-2 family transposase -
C770_RS39105 770579..771838 + 1260 WP_014526646.1 group II intron reverse transcriptase/maturase -
C770_RS39110 771919..772407 + 489 Protein_718 IS630-like element ISRm2011-2 family transposase -
C770_RS39115 772440..772784 - 345 WP_015242243.1 hypothetical protein -
C770_RS39120 772784..773887 - 1104 WP_015242244.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1417907 1417907


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(18-55)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14650.90 Da        Isoelectric Point: 4.6676

>T28627 WP_017277131.1 NC_019848:768909-769328 [Sinorhizobium meliloti GR4]
VSSLYMLDTNIVSELARNPQGAVAKRIAEVGPDAICVSIITAAELRYGCAKKGSPKLLAQIETILGSMQVLALDAPADAE
YGGIRAELEAACKPIGPNDLFIAAHACMLGAVLVTANSSEFTRVRDLKVENWLDFTSSG

Download         Length: 420 bp

>T28627 NC_019848:768909-769328 [Sinorhizobium meliloti GR4]
GTGAGCAGCCTCTACATGCTGGACACCAATATCGTGTCCGAGCTTGCGCGAAACCCACAGGGCGCTGTGGCTAAACGTAT
TGCCGAGGTAGGACCGGACGCAATCTGCGTCAGCATCATTACGGCGGCAGAGTTACGCTATGGATGCGCCAAGAAGGGAT
CACCGAAACTGCTGGCGCAGATCGAGACCATTCTTGGAAGTATGCAAGTGCTTGCGCTCGATGCGCCTGCTGATGCCGAA
TACGGCGGCATCCGGGCTGAACTGGAGGCCGCTTGTAAGCCCATCGGCCCGAATGACCTGTTCATCGCCGCTCATGCCTG
TATGCTTGGAGCGGTGCTGGTAACGGCCAACAGTAGCGAGTTCACACGCGTTCGTGATCTCAAGGTCGAGAACTGGCTGG
ATTTCACTTCTTCGGGTTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10157.65 Da        Isoelectric Point: 4.6899

>AT28627 WP_015242241.1 NC_019848:768643-768912 [Sinorhizobium meliloti GR4]
MPQLRHNEPAPPREAKLFRNNRSQAVRIPADFELPGDRVMIHRDGDRLIIEPVLRKNLLEVLAGLEPLGSEDNFPDVDET
LLPVKEIDL

Download         Length: 270 bp

>AT28627 NC_019848:768643-768912 [Sinorhizobium meliloti GR4]
ATGCCCCAACTCCGACACAACGAACCAGCGCCGCCAAGGGAAGCCAAGCTCTTCCGAAATAATAGAAGTCAGGCTGTACG
TATCCCCGCTGATTTTGAGCTTCCCGGCGATCGGGTGATGATCCATCGGGACGGAGATCGGCTGATAATAGAGCCGGTGC
TCCGCAAGAACTTGCTGGAAGTGCTGGCTGGTTTGGAGCCGCTCGGGTCTGAAGATAACTTCCCCGACGTTGACGAAACC
CTGCTGCCGGTGAAAGAAATCGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References