286269

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3465333..3466554 Replicon chromosome
Accession NZ_LR130537
Organism Pseudomonas aeruginosa isolate paerg012

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag EJN51_RS16235 Protein ID WP_003102740.1
Coordinates 3465976..3466554 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EJN51_RS16230 Protein ID WP_003088112.1
Coordinates 3465333..3465887 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN51_RS16205 3460901..3461452 + 552 WP_003132721.1 XRE family transcriptional regulator -
EJN51_RS16210 3461449..3461847 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
EJN51_RS16215 3461860..3462183 - 324 WP_003102734.1 multidrug efflux SMR transporter -
EJN51_RS16220 3462514..3462975 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
EJN51_RS16225 3462980..3465175 + 2196 WP_014603034.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
EJN51_RS16230 3465333..3465887 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
EJN51_RS16235 3465976..3466554 + 579 WP_003102740.1 HD domain-containing protein Toxin
EJN51_RS16240 3466662..3467849 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
EJN51_RS16245 3467839..3470010 - 2172 WP_014603035.1 type I secretion system permease/ATPase -
EJN51_RS16250 3470000..3471277 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T286269 WP_003102740.1 NZ_LR130537:3465976-3466554 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT286269 WP_003088112.1 NZ_LR130537:3465333-3465887 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References