Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4385971..4387229 Replicon chromosome
Accession NZ_LR130535
Organism Pseudomonas aeruginosa isolate paerg011

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag EJN52_RS20660 Protein ID WP_003163133.1
Coordinates 4385971..4386726 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag EJN52_RS20665 Protein ID WP_003086329.1
Coordinates 4386861..4387229 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN52_RS20650 4381143..4383686 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
EJN52_RS20655 4383841..4385202 - 1362 WP_079262974.1 DNA recombination protein RmuC -
EJN52_RS20660 4385971..4386726 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
EJN52_RS20665 4386861..4387229 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
EJN52_RS20670 4387302..4388588 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
EJN52_RS20675 4388644..4390233 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
EJN52_RS20680 4390312..4390788 + 477 WP_003112531.1 hypothetical protein -
EJN52_RS30580 4390791..4391066 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T286260 WP_003163133.1 NZ_LR130535:c4386726-4385971 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT286260 WP_003086329.1 NZ_LR130535:c4387229-4386861 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References