Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 210857..211393 Replicon plasmid pRmeGR4b
Accession NC_019847
Organism Sinorhizobium meliloti GR4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag C770_RS51095 Protein ID WP_080991220.1
Coordinates 210857..211126 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag C770_RS35410 Protein ID WP_015241718.1
Coordinates 211133..211393 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C770_RS35395 208337..208677 + 341 Protein_220 aldehyde dehydrogenase family protein -
C770_RS35400 209380..210489 + 1110 WP_015241716.1 hypothetical protein -
C770_RS35405 210555..210808 - 254 Protein_222 hypothetical protein -
C770_RS51095 210857..211126 - 270 WP_080991220.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C770_RS35410 211133..211393 - 261 WP_015241718.1 ribbon-helix-helix domain-containing protein Antitoxin
C770_RS53725 211882..212268 - 387 Protein_225 transposase -
C770_RS35415 212777..212965 + 189 WP_015241721.1 hypothetical protein -
C770_RS35420 213316..214593 + 1278 WP_015241722.1 replication protein C domain-containing protein -
C770_RS35425 214605..215102 + 498 WP_041169709.1 thermonuclease family protein -
C770_RS35430 215496..215828 + 333 WP_015241724.1 DUF736 family protein -
C770_RS35435 215950..216153 + 204 WP_015241725.1 antitoxin VbhA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - htpB 1..225725 225725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-88)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10581.07 Da        Isoelectric Point: 9.5846

>T28626 WP_080991220.1 NC_019847:c211126-210857 [Sinorhizobium meliloti GR4]
MEWTSKAVADLGRLYDFLAPVNRQAAARTVQSLTSAPARLLEQPRIGERLEEFDPREVRRILVGHYEIRYEIRQSTIYVL
RLWHTREDR

Download         Length: 270 bp

>T28626 NC_019847:c211126-210857 [Sinorhizobium meliloti GR4]
TTGGAGTGGACGAGTAAGGCAGTCGCCGATCTTGGGCGCCTCTATGATTTCCTGGCACCGGTAAATCGGCAAGCCGCGGC
TCGTACTGTGCAATCGTTGACGAGCGCTCCAGCACGCCTGCTCGAACAACCGCGCATCGGCGAACGGCTGGAGGAATTCG
ACCCTCGAGAGGTTCGGCGAATTCTCGTTGGCCATTACGAAATACGGTATGAGATCCGGCAGTCGACGATCTACGTCCTG
CGGCTTTGGCATACGCGTGAAGACCGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9682.10 Da        Isoelectric Point: 4.8307

>AT28626 WP_015241718.1 NC_019847:c211393-211133 [Sinorhizobium meliloti GR4]
METKVLTAHVPLPLAEKVDQIAARLERSRGWIVKQALTAWVDQEEERRRLTLEALADVDAGRVIDHQAVQAWADSLECDK
PLSLPL

Download         Length: 261 bp

>AT28626 NC_019847:c211393-211133 [Sinorhizobium meliloti GR4]
ATGGAAACGAAGGTGCTGACGGCGCACGTACCACTGCCGCTCGCCGAGAAAGTCGATCAGATCGCGGCCCGCCTTGAGCG
CTCGCGCGGGTGGATCGTCAAGCAGGCGCTGACCGCCTGGGTCGATCAGGAAGAGGAGCGCCGACGCTTGACGCTGGAAG
CGCTTGCCGACGTCGACGCTGGCCGCGTTATCGATCACCAGGCCGTCCAGGCCTGGGCCGACAGTCTTGAGTGTGACAAG
CCGCTCTCCCTGCCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References