286254

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4722854..4723547 Replicon chromosome
Accession NZ_LR130534
Organism Pseudomonas aeruginosa isolate paerg005

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag EJN62_RS22600 Protein ID WP_003151133.1
Coordinates 4722854..4723231 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag EJN62_RS22605 Protein ID WP_001172026.1
Coordinates 4723212..4723547 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN62_RS22585 4717965..4718810 - 846 WP_003464995.1 AraC family transcriptional regulator -
EJN62_RS22590 4719047..4722076 - 3030 WP_032432545.1 Tn3 family transposase -
EJN62_RS22595 4722060..4722662 - 603 WP_010465829.1 recombinase family protein -
EJN62_RS22600 4722854..4723231 + 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJN62_RS22605 4723212..4723547 + 336 WP_001172026.1 helix-turn-helix domain-containing protein Antitoxin
EJN62_RS22610 4723562..4723896 + 335 Protein_4349 transposase -
EJN62_RS22615 4723920..4724246 + 327 WP_000091614.1 hypothetical protein -
EJN62_RS22620 4724243..4724623 + 381 WP_001054412.1 hypothetical protein -
EJN62_RS22625 4724741..4725079 + 339 WP_125080705.1 DUF3391 domain-containing protein -
EJN62_RS22630 4725126..4726040 + 915 WP_001736514.1 HD domain-containing protein -
EJN62_RS22635 4726450..4726689 + 240 WP_034011918.1 ribbon-helix-helix domain-containing protein -
EJN62_RS22640 4726689..4727099 + 411 WP_034011919.1 putative toxin-antitoxin system toxin component, PIN family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4705205..4732631 27426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T286254 WP_003151133.1 NZ_LR130534:4722854-4723231 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT286254 WP_001172026.1 NZ_LR130534:4723212-4723547 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References