286253

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3901514..3902734 Replicon chromosome
Accession NZ_LR130534
Organism Pseudomonas aeruginosa isolate paerg005

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag EJN62_RS18560 Protein ID WP_003110488.1
Coordinates 3902156..3902734 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EJN62_RS18555 Protein ID WP_003088112.1
Coordinates 3901514..3902068 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN62_RS18530 3897082..3897633 + 552 WP_003132721.1 XRE family transcriptional regulator -
EJN62_RS18535 3897630..3898028 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
EJN62_RS18540 3898041..3898364 - 324 WP_003102734.1 multidrug efflux SMR transporter -
EJN62_RS18545 3898695..3899156 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
EJN62_RS18550 3899161..3901356 + 2196 WP_023095788.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
EJN62_RS18555 3901514..3902068 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
EJN62_RS18560 3902156..3902734 + 579 WP_003110488.1 HD domain-containing protein Toxin
EJN62_RS18565 3902844..3904031 - 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
EJN62_RS18570 3904021..3906192 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
EJN62_RS18575 3906182..3907459 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T286253 WP_003110488.1 NZ_LR130534:3902156-3902734 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT286253 WP_003088112.1 NZ_LR130534:3901514-3902068 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References