286252

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2485579..2486618 Replicon chromosome
Accession NZ_LR130534
Organism Pseudomonas aeruginosa isolate paerg005

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag EJN62_RS11950 Protein ID WP_100773622.1
Coordinates 2486043..2486618 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A7L5F0B4
Locus tag EJN62_RS11945 Protein ID WP_043156233.1
Coordinates 2485579..2486046 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN62_RS11910 2480958..2482388 - 1431 WP_009516218.1 TIGR03752 family integrating conjugative element protein -
EJN62_RS11915 2482378..2483286 - 909 WP_125075551.1 TIGR03749 family integrating conjugative element protein -
EJN62_RS11920 2483283..2483972 - 690 WP_100773626.1 TIGR03746 family integrating conjugative element protein -
EJN62_RS11925 2483969..2484367 - 399 WP_100773625.1 TIGR03750 family conjugal transfer protein -
EJN62_RS11930 2484379..2484738 - 360 WP_100773624.1 TIGR03745 family integrating conjugative element membrane protein -
EJN62_RS11935 2484755..2484988 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
EJN62_RS11940 2484985..2485365 - 381 WP_100773623.1 RAQPRD family integrative conjugative element protein -
EJN62_RS11945 2485579..2486046 + 468 WP_043156233.1 helix-turn-helix domain-containing protein Antitoxin
EJN62_RS11950 2486043..2486618 + 576 WP_100773622.1 PIN domain-containing protein Toxin
EJN62_RS11955 2486636..2487550 + 915 WP_100773621.1 AAA family ATPase -
EJN62_RS11960 2487547..2488017 + 471 WP_100773620.1 hypothetical protein -
EJN62_RS11965 2488014..2488514 + 501 WP_100773619.1 HORMA domain containing protein -
EJN62_RS11970 2488514..2489416 + 903 WP_100773618.1 nucleotidyltransferase domain-containing protein -
EJN62_RS11975 2489453..2490178 + 726 WP_100773617.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2442353..2528671 86318


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

SinI-like, DNA-binding domain

(84-131)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21570.58 Da        Isoelectric Point: 5.6513

>T286252 WP_100773622.1 NZ_LR130534:2486043-2486618 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQTIHEEWKRNLLINRPDLTRAQVDRTSDLMDRAIPDGLVEGY
ESLAAGLTLPDPDDRHVLAAAIRCGASVIVTFNQRDFPNELLAPYGVESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLRN
PTIDVDRYLDILLRQGLVQTTKVLAGYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17251.62 Da        Isoelectric Point: 5.9214

>AT286252 WP_043156233.1 NZ_LR130534:2485579-2486046 [Pseudomonas aeruginosa]
MTVTAQSKMTLPAEGEVKAAVQGQRALAAYLATQFETQHIQIFDDQKQAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELTQQSQELGMGYE

Download         Length: 468 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7L5F0B4

References