Detailed information of TA system TA286249

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 1690487..1692182
• Replicon: chromosome
• Accession: NZ_LR130534
• Organism: Pseudomonas aeruginosa isolate paerg005

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: EJN62_RS08050
• Protein ID: WP_023095293.1
• Coordinates: 1690487..1691356 (+)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: Q9HYA1
• Locus tag: EJN62_RS08055
• Protein ID: WP_003112902.1
• Coordinates: 1691349..1692182 (+)
• Length: 278 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJN62_RS08025	1686495..1687346	+	852	WP_003130104.1	ABC transporter ATP-binding protein	-
EJN62_RS08030	1687387..1688394	+	1008	WP_022579704.1	ABC transporter substrate-binding protein	-
EJN62_RS08035	1688391..1689167	+	777	WP_003112898.1	ABC transporter permease	-
EJN62_RS08040	1689173..1689934	+	762	WP_003112899.1	SDR family oxidoreductase	-
EJN62_RS08045	1689948..1690478	+	531	WP_003112900.1	cupin domain-containing protein	-
EJN62_RS08050	1690487..1691356	+	870	WP_023095293.1	alpha/beta hydrolase	Toxin
EJN62_RS08055	1691349..1692182	+	834	WP_003112902.1	IclR family transcriptional regulator	Antitoxin
EJN62_RS08060	1692169..1692966	+	798	WP_022579702.1	SDR family oxidoreductase	-
EJN62_RS08065	1692959..1694641	+	1683	WP_003112904.1	thiamine pyrophosphate-binding protein	-
EJN62_RS08070	1694652..1695455	+	804	WP_003112905.1	aspartate dehydrogenase	-
EJN62_RS08075	1695467..1696951	+	1485	WP_022579701.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (41-272)

Antitoxin

• Transcription regulator IclR, N-terminal (16-66)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 30379.61 Da
• Isoelectric Point: 6.8139

>T286249 WP_023095293.1 NZ_LR130534:1690487-1691356 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPISGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Nucleotide

• Length: 870 bp

Antitoxin

Protein

• Length: 278 a.a.
• Molecular weight: 30877.26 Da
• Isoelectric Point: 5.7725

>AT286249 WP_003112902.1 NZ_LR130534:1691349-1692182 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Nucleotide

• Length: 834 bp

Structures

Antitoxin

• AlphaFold DB: Q9HYA1