286247

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 5801490..5802529 Replicon chromosome
Accession NZ_LR130533
Organism Pseudomonas aeruginosa isolate paerg009

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag EJN60_RS27950 Protein ID WP_100773622.1
Coordinates 5801954..5802529 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A7L5F0B4
Locus tag EJN60_RS27945 Protein ID WP_043156233.1
Coordinates 5801490..5801957 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN60_RS27910 5796869..5798299 - 1431 WP_009516218.1 TIGR03752 family integrating conjugative element protein -
EJN60_RS27915 5798289..5799197 - 909 WP_125075551.1 TIGR03749 family integrating conjugative element protein -
EJN60_RS27920 5799194..5799883 - 690 WP_100773626.1 TIGR03746 family integrating conjugative element protein -
EJN60_RS27925 5799880..5800278 - 399 WP_100773625.1 TIGR03750 family conjugal transfer protein -
EJN60_RS27930 5800290..5800649 - 360 WP_100773624.1 TIGR03745 family integrating conjugative element membrane protein -
EJN60_RS27935 5800666..5800899 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
EJN60_RS27940 5800896..5801276 - 381 WP_100773623.1 RAQPRD family integrative conjugative element protein -
EJN60_RS27945 5801490..5801957 + 468 WP_043156233.1 helix-turn-helix domain-containing protein Antitoxin
EJN60_RS27950 5801954..5802529 + 576 WP_100773622.1 PIN domain-containing protein Toxin
EJN60_RS27955 5802547..5803461 + 915 WP_100773621.1 AAA family ATPase -
EJN60_RS27960 5803458..5803928 + 471 WP_100773620.1 hypothetical protein -
EJN60_RS27965 5803925..5804425 + 501 WP_100773619.1 HORMA domain containing protein -
EJN60_RS27970 5804425..5805327 + 903 WP_100773618.1 nucleotidyltransferase domain-containing protein -
EJN60_RS27975 5805364..5806089 + 726 WP_100773617.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5758264..5844582 86318


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

SinI-like, DNA-binding domain

(84-131)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21570.58 Da        Isoelectric Point: 5.6513

>T286247 WP_100773622.1 NZ_LR130533:5801954-5802529 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQTIHEEWKRNLLINRPDLTRAQVDRTSDLMDRAIPDGLVEGY
ESLAAGLTLPDPDDRHVLAAAIRCGASVIVTFNQRDFPNELLAPYGVESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLRN
PTIDVDRYLDILLRQGLVQTTKVLAGYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17251.62 Da        Isoelectric Point: 5.9214

>AT286247 WP_043156233.1 NZ_LR130533:5801490-5801957 [Pseudomonas aeruginosa]
MTVTAQSKMTLPAEGEVKAAVQGQRALAAYLATQFETQHIQIFDDQKQAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELTQQSQELGMGYE

Download         Length: 468 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7L5F0B4

References