Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3462957..3463462 Replicon chromosome
Accession NZ_LR130533
Organism Pseudomonas aeruginosa isolate paerg009

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag EJN60_RS16680 Protein ID WP_003083773.1
Coordinates 3462957..3463238 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag EJN60_RS16685 Protein ID WP_003083775.1
Coordinates 3463235..3463462 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN60_RS16655 3458208..3459557 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
EJN60_RS16660 3459606..3460292 + 687 WP_003083762.1 FadR family transcriptional regulator -
EJN60_RS16665 3460393..3461127 + 735 WP_003083764.1 GntR family transcriptional regulator -
EJN60_RS16670 3461331..3461717 + 387 WP_003083767.1 aegerolysin family protein -
EJN60_RS16675 3461749..3462657 - 909 WP_003083769.1 LysR family transcriptional regulator -
EJN60_RS16680 3462957..3463238 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
EJN60_RS16685 3463235..3463462 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
EJN60_RS16690 3463638..3464258 - 621 WP_003101226.1 hypothetical protein -
EJN60_RS16695 3464359..3464859 + 501 WP_003083778.1 LEA type 2 family protein -
EJN60_RS16700 3464932..3465273 + 342 WP_014603467.1 alkylphosphonate utilization protein -
EJN60_RS16705 3465357..3466784 - 1428 WP_003083784.1 GABA permease -
EJN60_RS16710 3466953..3468446 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T286243 WP_003083773.1 NZ_LR130533:c3463238-3462957 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT286243 WP_003083775.1 NZ_LR130533:c3463462-3463235 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References