Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 860994..862214 Replicon chromosome
Accession NZ_LR130533
Organism Pseudomonas aeruginosa isolate paerg009

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag EJN60_RS04295 Protein ID WP_003110488.1
Coordinates 860994..861572 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EJN60_RS04300 Protein ID WP_003088112.1
Coordinates 861660..862214 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN60_RS04280 856269..857546 + 1278 WP_003088104.1 TolC family protein -
EJN60_RS04285 857536..859707 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
EJN60_RS04290 859697..860884 + 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
EJN60_RS04295 860994..861572 - 579 WP_003110488.1 HD domain-containing protein Toxin
EJN60_RS04300 861660..862214 - 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
EJN60_RS04305 862372..864567 - 2196 WP_023095788.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
EJN60_RS04310 864572..865033 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
EJN60_RS04315 865364..865687 + 324 WP_003102734.1 multidrug efflux SMR transporter -
EJN60_RS04320 865700..866098 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
EJN60_RS04325 866095..866646 - 552 WP_003132721.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T286240 WP_003110488.1 NZ_LR130533:c861572-860994 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT286240 WP_003088112.1 NZ_LR130533:c862214-861660 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References