Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 36737..37430 Replicon chromosome
Accession NZ_LR130533
Organism Pseudomonas aeruginosa isolate paerg009

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag EJN60_RS00235 Protein ID WP_003151133.1
Coordinates 37053..37430 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag EJN60_RS00230 Protein ID WP_001172026.1
Coordinates 36737..37072 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN60_RS00195 33164..33574 - 411 WP_034011919.1 putative toxin-antitoxin system toxin component, PIN family -
EJN60_RS00200 33574..33813 - 240 WP_034011918.1 ribbon-helix-helix domain-containing protein -
EJN60_RS00205 34223..35137 - 915 WP_001736514.1 HD domain-containing protein -
EJN60_RS00210 35184..35543 - 360 WP_125075509.1 DUF3391 domain-containing protein -
EJN60_RS00215 35661..36041 - 381 WP_001054412.1 hypothetical protein -
EJN60_RS00220 36038..36364 - 327 WP_000091614.1 hypothetical protein -
EJN60_RS00225 36388..36722 - 335 Protein_40 transposase -
EJN60_RS00230 36737..37072 - 336 WP_001172026.1 helix-turn-helix domain-containing protein Antitoxin
EJN60_RS00235 37053..37430 - 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJN60_RS00240 37622..38224 + 603 WP_010465829.1 recombinase family protein -
EJN60_RS00245 38208..41237 + 3030 WP_032432545.1 Tn3 family transposase -
EJN60_RS00250 41474..42319 + 846 WP_003464995.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 27990..55447 27457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T286239 WP_003151133.1 NZ_LR130533:c37430-37053 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT286239 WP_001172026.1 NZ_LR130533:c37072-36737 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References