Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4536800..4537431 Replicon chromosome
Accession NZ_LR130532
Organism Escherichia coli isolate ecoli019

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag EJK95_RS22315 Protein ID WP_001259388.1
Coordinates 4537156..4537431 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag EJK95_RS22310 Protein ID WP_000593555.1
Coordinates 4536800..4537159 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJK95_RS22280 4531912..4532385 + 474 WP_001161553.1 PTS sugar transporter subunit IIA -
EJK95_RS22285 4532382..4532663 + 282 WP_000084022.1 PTS sugar transporter subunit IIB -
EJK95_RS22290 4532740..4534098 + 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
EJK95_RS22295 4534091..4535599 + 1509 WP_001298718.1 carbohydrate kinase -
EJK95_RS22300 4535589..4535858 + 270 WP_000933060.1 HPr family phosphocarrier protein -
EJK95_RS22305 4535890..4536750 + 861 WP_001131783.1 class II aldolase -
EJK95_RS22310 4536800..4537159 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EJK95_RS22315 4537156..4537431 - 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
EJK95_RS22320 4537504..4538628 - 1125 WP_001314210.1 ABC transporter permease -
EJK95_RS22325 4538628..4541363 - 2736 WP_000149125.1 ribosome-associated ATPase/putative transporter RbbA -
EJK95_RS22330 4541360..4542427 - 1068 WP_000361485.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T286238 WP_001259388.1 NZ_LR130532:c4537431-4537156 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT286238 WP_000593555.1 NZ_LR130532:c4537159-4536800 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References