286234

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3986938..3987592 Replicon chromosome
Accession NZ_LR130532
Organism Escherichia coli isolate ecoli019

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag EJK95_RS19460 Protein ID WP_000244781.1
Coordinates 3986938..3987345 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag EJK95_RS19465 Protein ID WP_000354046.1
Coordinates 3987326..3987592 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJK95_RS19440 3982895..3984628 - 1734 WP_000813218.1 single-stranded-DNA-specific exonuclease RecJ -
EJK95_RS19445 3984634..3985344 - 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EJK95_RS19450 3985369..3986265 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
EJK95_RS19455 3986377..3986898 + 522 WP_001055874.1 flavodoxin FldB -
EJK95_RS19460 3986938..3987345 - 408 WP_000244781.1 protein YgfX Toxin
EJK95_RS19465 3987326..3987592 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
EJK95_RS19470 3987835..3988815 + 981 WP_000886095.1 tRNA-modifying protein YgfZ -
EJK95_RS19475 3989011..3989670 - 660 WP_000250274.1 hemolysin III family protein -
EJK95_RS19480 3989834..3990145 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
EJK95_RS19485 3990190..3991623 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
EJK95_RS19490 3991680..3992423 - 744 WP_000951951.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T286234 WP_000244781.1 NZ_LR130532:c3987345-3986938 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT286234 WP_000354046.1 NZ_LR130532:c3987592-3987326 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References