286233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3845490..3846073 Replicon chromosome
Accession NZ_LR130532
Organism Escherichia coli isolate ecoli019

Toxin (Protein)


Gene name mazF Uniprot ID U9XFN8
Locus tag EJK95_RS18785 Protein ID WP_000254745.1
Coordinates 3845490..3845825 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag EJK95_RS18790 Protein ID WP_000581937.1
Coordinates 3845825..3846073 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJK95_RS18770 3841377..3842675 - 1299 WP_000036723.1 phosphopyruvate hydratase -
EJK95_RS18775 3842763..3844400 - 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
EJK95_RS18780 3844628..3845419 - 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
EJK95_RS18785 3845490..3845825 - 336 WP_000254745.1 endoribonuclease MazF Toxin
EJK95_RS18790 3845825..3846073 - 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EJK95_RS18795 3846151..3848385 - 2235 WP_000226815.1 GTP pyrophosphokinase -
EJK95_RS18800 3848433..3849734 - 1302 WP_000046785.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12158.08 Da        Isoelectric Point: 8.4777

>T286233 WP_000254745.1 NZ_LR130532:c3845825-3845490 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPYTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT286233 WP_000581937.1 NZ_LR130532:c3846073-3845825 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYM3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LMB4

References