Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3549671..3550296 Replicon chromosome
Accession NZ_LR130532
Organism Escherichia coli isolate ecoli019

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EJK95_RS17330 Protein ID WP_000911330.1
Coordinates 3549671..3550069 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag EJK95_RS17335 Protein ID WP_000450524.1
Coordinates 3550069..3550296 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJK95_RS17310 3545578..3545778 + 201 WP_000383836.1 YpfN family protein -
EJK95_RS17315 3545859..3546557 - 699 WP_000679812.1 esterase -
EJK95_RS17320 3546631..3548646 - 2016 WP_000829354.1 tRNA cytosine(34) acetyltransferase TmcA -
EJK95_RS17325 3548661..3549524 - 864 WP_001267508.1 neutral zinc metallopeptidase -
EJK95_RS17330 3549671..3550069 - 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
EJK95_RS17335 3550069..3550296 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
EJK95_RS17340 3550450..3551163 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EJK95_RS17345 3551376..3552410 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
EJK95_RS17350 3552427..3553305 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
EJK95_RS17355 3553451..3554023 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
EJK95_RS17360 3554023..3554493 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T286232 WP_000911330.1 NZ_LR130532:c3550069-3549671 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT286232 WP_000450524.1 NZ_LR130532:c3550296-3550069 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References