Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1217001..1217619 Replicon chromosome
Accession NZ_LR130532
Organism Escherichia coli isolate ecoli019

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EJK95_RS05770 Protein ID WP_001291435.1
Coordinates 1217001..1217219 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EJK95_RS05775 Protein ID WP_000344800.1
Coordinates 1217245..1217619 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJK95_RS05735 1212290..1212862 + 573 WP_000779831.1 YbaY family lipoprotein -
EJK95_RS05740 1212893..1213204 - 312 WP_000409911.1 MGMT family protein -
EJK95_RS05750 1213583..1213936 + 354 WP_000878140.1 DUF1428 domain-containing protein -
EJK95_RS05755 1213978..1215528 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EJK95_RS05760 1215692..1216162 - 471 WP_000136192.1 YlaC family protein -
EJK95_RS05765 1216278..1216829 - 552 WP_000102568.1 maltose O-acetyltransferase -
EJK95_RS05770 1217001..1217219 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EJK95_RS05775 1217245..1217619 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EJK95_RS05780 1218164..1221313 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
EJK95_RS05785 1221336..1222529 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T286219 WP_001291435.1 NZ_LR130532:c1217219-1217001 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT286219 WP_000344800.1 NZ_LR130532:c1217619-1217245 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References