286218

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1182704..1183541 Replicon chromosome
Accession NZ_LR130532
Organism Escherichia coli isolate ecoli019

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag EJK95_RS05600 Protein ID WP_000227784.1
Coordinates 1182704..1183246 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag EJK95_RS05605 Protein ID WP_001297137.1
Coordinates 1183230..1183541 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJK95_RS05580 1178248..1179159 - 912 WP_000705874.1 2-dehydropantoate 2-reductase -
EJK95_RS05585 1179327..1179818 + 492 WP_001138904.1 nucleotide binding protein YajQ -
EJK95_RS05590 1179946..1181310 - 1365 WP_001000978.1 MFS transporter -
EJK95_RS05595 1181713..1182648 + 936 WP_001297127.1 sel1 repeat family protein -
EJK95_RS05600 1182704..1183246 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
EJK95_RS05605 1183230..1183541 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
EJK95_RS05610 1183726..1184616 - 891 WP_000971336.1 heme o synthase -
EJK95_RS05615 1184628..1184957 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
EJK95_RS05620 1184957..1185571 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
EJK95_RS05625 1185561..1187552 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
EJK95_RS05630 1187574..1188521 - 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T286218 WP_000227784.1 NZ_LR130532:c1183246-1182704 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT286218 WP_001297137.1 NZ_LR130532:c1183541-1183230 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References