286216

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 604716..605530 Replicon chromosome
Accession NZ_LR130532
Organism Escherichia coli isolate ecoli019

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag EJK95_RS02955 Protein ID WP_001054376.1
Coordinates 605273..605530 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag EJK95_RS02950 Protein ID WP_001309181.1
Coordinates 604716..605261 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJK95_RS02925 600407..601720 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
EJK95_RS02930 601732..602010 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
EJK95_RS02935 602007..603128 - 1122 WP_000010829.1 M42 family metallopeptidase -
EJK95_RS24745 603373..603489 - 117 Protein_539 VOC family protein -
EJK95_RS02940 603527..603745 - 219 Protein_540 hypothetical protein -
EJK95_RS02945 603914..604660 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
EJK95_RS02950 604716..605261 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
EJK95_RS02955 605273..605530 - 258 WP_001054376.1 hypothetical protein Toxin
EJK95_RS02960 605907..606152 - 246 Protein_544 GNAT family N-acetyltransferase -
EJK95_RS02965 606268..607508 + 1241 Protein_545 helicase YjhR -
EJK95_RS02970 608091..609071 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
EJK95_RS02975 609136..610242 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB / fimE / fimA / fimI / fimC 568062..616495 48433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T286216 WP_001054376.1 NZ_LR130532:c605530-605273 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT286216 WP_001309181.1 NZ_LR130532:c605261-604716 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References