Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3893181..3893686 Replicon chromosome
Accession NZ_LR130531
Organism Pseudomonas aeruginosa isolate paerg004

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag EJM92_RS18250 Protein ID WP_003083773.1
Coordinates 3893181..3893462 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag EJM92_RS18255 Protein ID WP_003083775.1
Coordinates 3893459..3893686 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJM92_RS18225 3888432..3889781 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
EJM92_RS18230 3889830..3890516 + 687 WP_003083762.1 FadR family transcriptional regulator -
EJM92_RS18235 3890617..3891351 + 735 WP_003117208.1 GntR family transcriptional regulator -
EJM92_RS18240 3891555..3891941 + 387 WP_014602345.1 aegerolysin family protein -
EJM92_RS18245 3891973..3892881 - 909 WP_003083769.1 LysR family transcriptional regulator -
EJM92_RS18250 3893181..3893462 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
EJM92_RS18255 3893459..3893686 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
EJM92_RS18260 3893862..3894482 - 621 WP_003101226.1 hypothetical protein -
EJM92_RS18265 3894583..3895083 + 501 WP_003112629.1 LEA type 2 family protein -
EJM92_RS18270 3895156..3895497 + 342 WP_003101229.1 alkylphosphonate utilization protein -
EJM92_RS18275 3895579..3897006 - 1428 WP_003083784.1 GABA permease -
EJM92_RS18280 3897175..3898668 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T286211 WP_003083773.1 NZ_LR130531:c3893462-3893181 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT286211 WP_003083775.1 NZ_LR130531:c3893686-3893459 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References