28621

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2173556..2174210 Replicon chromosome
Accession NC_019845
Organism Sinorhizobium meliloti GR4

Toxin (Protein)


Gene name hicA Uniprot ID H0G1A3
Locus tag C770_RS10335 Protein ID WP_003530010.1
Coordinates 2173556..2173744 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q92NX0
Locus tag C770_RS10340 Protein ID WP_010969659.1
Coordinates 2173749..2174210 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C770_RS10320 2170123..2171433 + 1311 WP_010969656.1 HlyD family type I secretion periplasmic adaptor subunit -
C770_RS10325 2171458..2172429 - 972 WP_017265202.1 glycosyltransferase family 2 protein -
C770_RS10330 2172610..2173379 - 770 Protein_2030 LpsS -
C770_RS10335 2173556..2173744 + 189 WP_003530010.1 type II toxin-antitoxin system HicA family toxin Toxin
C770_RS10340 2173749..2174210 + 462 WP_010969659.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C770_RS10350 2174529..2175446 - 918 WP_003530005.1 PhzF family phenazine biosynthesis protein -
C770_RS10355 2175623..2176372 - 750 WP_010969660.1 NUDIX hydrolase -
C770_RS10360 2176375..2177481 - 1107 WP_003530001.1 endonuclease -
C770_RS10365 2177632..2178075 - 444 WP_003529999.1 TIGR02594 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6971.15 Da        Isoelectric Point: 11.0889

>T28621 WP_003530010.1 NC_019845:2173556-2173744 [Sinorhizobium meliloti GR4]
MKSGDIIAALQKDGWYEVATKGSHVQFKHPKKHGRVTVPHPKRDLPIGTLRSIEKQSGLKLR

Download         Length: 189 bp

>T28621 NC_019845:2173556-2173744 [Sinorhizobium meliloti GR4]
ATGAAGAGCGGCGACATTATTGCAGCATTGCAGAAGGACGGATGGTACGAGGTTGCGACCAAGGGCAGCCACGTTCAATT
CAAACATCCGAAAAAGCACGGCCGGGTTACCGTTCCTCACCCGAAGAGGGATCTACCAATCGGTACCCTCAGGAGCATTG
AAAAGCAGTCCGGTTTGAAATTGAGGTAA

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16293.17 Da        Isoelectric Point: 4.3990

>AT28621 WP_010969659.1 NC_019845:2173749-2174210 [Sinorhizobium meliloti GR4]
MRNYIGLIHKDAESDYGVSFPDFSGVVTAGADLDDARAMAEEALALHIEGLVEDGEAIPEPSSLEVVMSDAENRDCVAIL
VAVKTEAKRAIRVNVTLPEGVLKQIDAFAEAHGLTRSGFLARAATHEIERANDGHDAYAESRLSALGTSSKNV

Download         Length: 462 bp

>AT28621 NC_019845:2173749-2174210 [Sinorhizobium meliloti GR4]
ATGCGCAACTATATCGGATTGATCCACAAGGACGCCGAGAGCGATTACGGCGTTTCCTTTCCTGATTTTTCCGGCGTCGT
GACCGCCGGTGCCGACCTCGACGACGCGCGCGCTATGGCAGAGGAAGCCTTGGCCTTGCATATTGAAGGGCTGGTAGAGG
ACGGCGAGGCCATCCCGGAGCCCTCCTCCCTTGAGGTTGTCATGTCCGACGCCGAGAACAGGGATTGCGTCGCTATTCTC
GTCGCGGTGAAAACCGAGGCAAAAAGAGCCATTCGAGTGAACGTTACGCTTCCCGAAGGTGTCCTGAAGCAGATAGATGC
CTTCGCCGAAGCCCACGGCCTTACGCGGTCTGGATTTCTTGCTCGTGCTGCAACGCACGAGATCGAACGGGCAAATGACG
GCCACGACGCCTATGCGGAATCCCGCTTGTCGGCTTTGGGCACTTCCAGCAAAAATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0G1A3

Antitoxin

Source ID Structure
AlphaFold DB Q92NX0

References