Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1703567..1704825 Replicon chromosome
Accession NZ_LR130531
Organism Pseudomonas aeruginosa isolate paerg004

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag EJM92_RS07830 Protein ID WP_003163133.1
Coordinates 1703567..1704322 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag EJM92_RS07835 Protein ID WP_003086329.1
Coordinates 1704457..1704825 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJM92_RS07820 1698739..1701282 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
EJM92_RS07825 1701437..1702798 - 1362 WP_079262974.1 DNA recombination protein RmuC -
EJM92_RS07830 1703567..1704322 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
EJM92_RS07835 1704457..1704825 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
EJM92_RS07840 1704898..1706184 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
EJM92_RS07845 1706240..1707829 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
EJM92_RS07850 1707908..1708384 + 477 WP_003112531.1 hypothetical protein -
EJM92_RS30635 1708387..1708662 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T286209 WP_003163133.1 NZ_LR130531:c1704322-1703567 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT286209 WP_003086329.1 NZ_LR130531:c1704825-1704457 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References