286205

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3465355..3466576 Replicon chromosome
Accession NZ_LR130530
Organism Pseudomonas aeruginosa isolate paerg003

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag EJ102_RS16225 Protein ID WP_003102740.1
Coordinates 3465998..3466576 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EJ102_RS16220 Protein ID WP_003088112.1
Coordinates 3465355..3465909 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ102_RS16195 3460923..3461474 + 552 WP_003132721.1 XRE family transcriptional regulator -
EJ102_RS16200 3461471..3461869 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
EJ102_RS16205 3461882..3462205 - 324 WP_003102734.1 multidrug efflux SMR transporter -
EJ102_RS16210 3462536..3462997 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
EJ102_RS16215 3463002..3465197 + 2196 WP_014603034.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
EJ102_RS16220 3465355..3465909 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
EJ102_RS16225 3465998..3466576 + 579 WP_003102740.1 HD domain-containing protein Toxin
EJ102_RS16230 3466684..3467871 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
EJ102_RS16235 3467861..3470032 - 2172 WP_014603035.1 type I secretion system permease/ATPase -
EJ102_RS16240 3470022..3471299 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T286205 WP_003102740.1 NZ_LR130530:3465998-3466576 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT286205 WP_003088112.1 NZ_LR130530:3465355-3465909 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References