Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5678841..5679511 Replicon chromosome
Accession NZ_LR130528
Organism Pseudomonas aeruginosa isolate paerg000

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EJN10_RS26980 Protein ID WP_023114647.1
Coordinates 5678841..5679260 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EJN10_RS26985 Protein ID WP_023114648.1
Coordinates 5679257..5679511 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN10_RS26950 5674794..5675252 + 459 WP_023114640.1 helix-turn-helix domain-containing protein -
EJN10_RS26955 5675291..5675659 - 369 WP_023114641.1 conjugal transfer transcriptional regulator TraJ -
EJN10_RS26960 5675662..5675946 - 285 WP_023114642.1 hypothetical protein -
EJN10_RS26965 5675958..5676200 - 243 WP_124034060.1 type I toxin-antitoxin system ptaRNA1 family toxin -
EJN10_RS26970 5676269..5677740 - 1472 Protein_5196 P-type conjugative transfer protein TrbL -
EJN10_RS31110 5677742..5677900 - 159 WP_172605026.1 hypothetical protein -
EJN10_RS26975 5677915..5678685 - 771 WP_023114646.1 P-type conjugative transfer protein TrbJ -
EJN10_RS26980 5678841..5679260 - 420 WP_023114647.1 type II toxin-antitoxin system VapC family toxin Toxin
EJN10_RS26985 5679257..5679511 - 255 WP_023114648.1 Arc family DNA-binding protein Antitoxin
EJN10_RS26990 5680806..5681783 - 978 WP_031637437.1 plasmid replication -
EJN10_RS26995 5681764..5682657 - 894 WP_031637438.1 helicase RepA family protein -
EJN10_RS27000 5682660..5682884 - 225 WP_023114650.1 AlpA family phage regulatory protein -
EJN10_RS27005 5682978..5683970 + 993 WP_023114651.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5675662..5685574 9912


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14925.16 Da        Isoelectric Point: 5.1890

>T286202 WP_023114647.1 NZ_LR130528:c5679260-5678841 [Pseudomonas aeruginosa]
MIVLDTNVVSEAMKPEPNPAVRAWLNEQVVETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHQ

Download         Length: 420 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9508.87 Da        Isoelectric Point: 6.4760

>AT286202 WP_023114648.1 NZ_LR130528:c5679511-5679257 [Pseudomonas aeruginosa]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRIRMGDALAELGRRVGLTNDDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References