286201

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4567208..4568250 Replicon chromosome
Accession NZ_LR130528
Organism Pseudomonas aeruginosa isolate paerg000

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag EJN10_RS21645 Protein ID WP_003153636.1
Coordinates 4567208..4567783 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag EJN10_RS21650 Protein ID WP_003050245.1
Coordinates 4567780..4568250 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN10_RS21610 4562406..4563131 - 726 WP_003050273.1 CBASS effector endonuclease NucC -
EJN10_RS21615 4563170..4563271 - 102 Protein_4161 nucleotidyltransferase -
EJN10_RS21625 4564509..4565312 - 804 Protein_4163 nucleotidyltransferase domain-containing protein -
EJN10_RS21630 4565312..4565812 - 501 WP_003090159.1 hypothetical protein -
EJN10_RS21635 4565809..4566279 - 471 WP_023114496.1 hypothetical protein -
EJN10_RS21640 4566276..4567190 - 915 WP_023114497.1 AAA family ATPase -
EJN10_RS21645 4567208..4567783 - 576 WP_003153636.1 PIN domain-containing protein Toxin
EJN10_RS21650 4567780..4568250 - 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
EJN10_RS21655 4568454..4568837 + 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
EJN10_RS21660 4568834..4569067 + 234 WP_003090170.1 TIGR03758 family integrating conjugative element protein -
EJN10_RS21665 4569084..4569443 + 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
EJN10_RS21670 4569455..4569853 + 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
EJN10_RS21675 4569850..4570542 + 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
EJN10_RS21680 4570539..4571450 + 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
EJN10_RS21685 4571440..4572860 + 1421 Protein_4175 TIGR03752 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T286201 WP_003153636.1 NZ_LR130528:c4567783-4567208 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT286201 WP_003050245.1 NZ_LR130528:c4568250-4567780 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References