Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3355994..3357215 Replicon chromosome
Accession NZ_LR130528
Organism Pseudomonas aeruginosa isolate paerg000

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EJN10_RS16105 Protein ID WP_003160088.1
Coordinates 3355994..3356572 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EJN10_RS16110 Protein ID WP_003088112.1
Coordinates 3356661..3357215 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN10_RS16090 3351271..3352547 + 1277 Protein_3097 TolC family protein -
EJN10_RS16095 3352537..3354708 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
EJN10_RS16100 3354698..3355885 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
EJN10_RS16105 3355994..3356572 - 579 WP_003160088.1 HD domain-containing protein Toxin
EJN10_RS16110 3356661..3357215 - 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
EJN10_RS16115 3357373..3359568 - 2196 WP_003160090.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
EJN10_RS16120 3359573..3360034 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
EJN10_RS16125 3360365..3360688 + 324 WP_003102734.1 multidrug efflux SMR transporter -
EJN10_RS16130 3360701..3361099 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
EJN10_RS16135 3361096..3361647 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T286200 WP_003160088.1 NZ_LR130528:c3356572-3355994 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT286200 WP_003088112.1 NZ_LR130528:c3357215-3356661 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References