Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2391433..2392691 Replicon chromosome
Accession NZ_LR130528
Organism Pseudomonas aeruginosa isolate paerg000

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag EJN10_RS11395 Protein ID WP_023114076.1
Coordinates 2391936..2392691 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag EJN10_RS11390 Protein ID WP_003086329.1
Coordinates 2391433..2391801 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN10_RS30945 2387597..2387872 + 276 WP_023088486.1 zinc ribbon domain-containing protein -
EJN10_RS11375 2387875..2388351 - 477 WP_003134036.1 elongation factor GreAB -
EJN10_RS11380 2388430..2390018 + 1589 Protein_2185 aldehyde dehydrogenase family protein -
EJN10_RS11385 2390074..2391360 + 1287 WP_003449000.1 FAD-binding oxidoreductase -
EJN10_RS11390 2391433..2391801 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
EJN10_RS11395 2391936..2392691 + 756 WP_023114076.1 RES family NAD+ phosphorylase Toxin
EJN10_RS11400 2393459..2394820 + 1362 WP_125121009.1 DNA recombination protein RmuC -
EJN10_RS11405 2394975..2397518 - 2544 WP_124101683.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28309.54 Da        Isoelectric Point: 8.3428

>T286199 WP_023114076.1 NZ_LR130528:2391936-2392691 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWKL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT286199 WP_003086329.1 NZ_LR130528:2391433-2391801 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References