Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142595..143100 Replicon chromosome
Accession NZ_LR130528
Organism Pseudomonas aeruginosa isolate paerg000

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag EJN10_RS00665 Protein ID WP_023114790.1
Coordinates 142595..142876 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag EJN10_RS00670 Protein ID WP_003083775.1
Coordinates 142873..143100 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN10_RS00640 137846..139195 + 1350 WP_124033873.1 C4-dicarboxylate transporter DctA -
EJN10_RS00645 139244..139930 + 687 WP_124033874.1 FadR family transcriptional regulator -
EJN10_RS00650 140031..140762 + 732 Protein_129 GntR family transcriptional regulator -
EJN10_RS00655 140969..141355 + 387 WP_014602345.1 aegerolysin family protein -
EJN10_RS00660 141387..142295 - 909 WP_003083769.1 LysR family transcriptional regulator -
EJN10_RS00665 142595..142876 - 282 WP_023114790.1 type II toxin-antitoxin system toxin ParE Toxin
EJN10_RS00670 142873..143100 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
EJN10_RS00675 143276..143896 - 621 WP_003101226.1 hypothetical protein -
EJN10_RS00680 143997..144497 + 501 WP_003101228.1 LEA type 2 family protein -
EJN10_RS00685 144570..144911 + 342 WP_003101229.1 alkylphosphonate utilization protein -
EJN10_RS00690 144993..146420 - 1428 WP_124033878.1 GABA permease -
EJN10_RS00695 146589..148082 - 1494 WP_016263977.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10464.21 Da        Isoelectric Point: 10.0014

>T286197 WP_023114790.1 NZ_LR130528:c142876-142595 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDKVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT286197 WP_003083775.1 NZ_LR130528:c143100-142873 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References