286195

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3256068..3256573 Replicon chromosome
Accession NZ_LR130527
Organism Pseudomonas aeruginosa isolate paerg002

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag EJN50_RS15520 Protein ID WP_003083773.1
Coordinates 3256068..3256349 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag EJN50_RS15525 Protein ID WP_003083775.1
Coordinates 3256346..3256573 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN50_RS15495 3251319..3252668 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
EJN50_RS15500 3252717..3253403 + 687 WP_003083762.1 FadR family transcriptional regulator -
EJN50_RS15505 3253504..3254238 + 735 WP_003117208.1 GntR family transcriptional regulator -
EJN50_RS15510 3254442..3254828 + 387 WP_014602345.1 aegerolysin family protein -
EJN50_RS15515 3254860..3255768 - 909 WP_003083769.1 LysR family transcriptional regulator -
EJN50_RS15520 3256068..3256349 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
EJN50_RS15525 3256346..3256573 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
EJN50_RS15530 3256749..3257369 - 621 WP_003101226.1 hypothetical protein -
EJN50_RS15535 3257470..3257970 + 501 WP_003112629.1 LEA type 2 family protein -
EJN50_RS15540 3258043..3258384 + 342 WP_003101229.1 alkylphosphonate utilization protein -
EJN50_RS15545 3258466..3259893 - 1428 WP_003083784.1 GABA permease -
EJN50_RS15550 3260062..3261555 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T286195 WP_003083773.1 NZ_LR130527:c3256349-3256068 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT286195 WP_003083775.1 NZ_LR130527:c3256573-3256346 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References