286170

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2345521..2346050 Replicon chromosome
Accession NZ_LR130515
Organism Staphylococcus aureus strain BPH2947 isolate BPH2947

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EW033_RS12425 Protein ID WP_000621175.1
Coordinates 2345521..2345883 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag EW033_RS12430 Protein ID WP_000948331.1
Coordinates 2345880..2346050 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW033_RS12400 2342500..2343270 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
EW033_RS12405 2343245..2343724 - 480 WP_001190829.1 anti-sigma B factor RsbW -
EW033_RS12410 2343726..2344052 - 327 WP_001052491.1 anti-sigma factor antagonist -
EW033_RS12415 2344171..2345172 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
EW033_RS12425 2345521..2345883 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EW033_RS12430 2345880..2346050 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EW033_RS12435 2346135..2347283 - 1149 WP_001281145.1 alanine racemase -
EW033_RS12440 2347349..2347708 - 360 WP_000581200.1 holo-ACP synthase -
EW033_RS12445 2347712..2348203 - 492 WP_001205910.1 PH domain-containing protein -
EW033_RS12450 2348190..2349773 - 1584 WP_129760524.1 PH domain-containing protein -
EW033_RS12455 2349766..2350245 - 480 WP_001287088.1 hypothetical protein -
EW033_RS12460 2350453..2351013 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286170 WP_000621175.1 NZ_LR130515:c2345883-2345521 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT286170 WP_000948331.1 NZ_LR130515:c2346050-2345880 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References