Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 960676..961181 Replicon chromosome
Accession NZ_LR130515
Organism Staphylococcus aureus strain BPH2947 isolate BPH2947

Toxin (Protein)


Gene name TscT Uniprot ID A0A0C6E6D5
Locus tag EW033_RS05025 Protein ID WP_001103946.1
Coordinates 960888..961181 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IA75
Locus tag EW033_RS05020 Protein ID WP_001058492.1
Coordinates 960676..960885 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW033_RS04985 956193..957413 - 1221 WP_000264182.1 site-specific integrase -
EW033_RS04990 957501..958229 - 729 WP_000733773.1 staphylococcal enterotoxin type K -
EW033_RS04995 958253..958981 - 729 WP_001033317.1 staphylococcal enterotoxin type Q -
EW033_RS05000 959156..959890 - 735 WP_000142630.1 helix-turn-helix domain-containing protein -
EW033_RS05005 960040..960252 + 213 WP_001063624.1 helix-turn-helix transcriptional regulator -
EW033_RS05010 960253..960525 + 273 WP_001138298.1 helix-turn-helix domain-containing protein -
EW033_RS05015 960537..960683 + 147 WP_000784885.1 hypothetical protein -
EW033_RS05020 960676..960885 + 210 WP_001058492.1 hypothetical protein Antitoxin
EW033_RS05025 960888..961181 + 294 WP_001103946.1 DUF1474 family protein Toxin
EW033_RS05030 961269..962138 + 870 WP_001002691.1 primase alpha helix C-terminal domain-containing protein -
EW033_RS05035 962155..963612 + 1458 WP_000432707.1 virulence-associated E family protein -
EW033_RS05040 963914..964276 + 363 WP_001039172.1 hypothetical protein -
EW033_RS05045 964278..964562 + 285 WP_000998180.1 hypothetical protein -
EW033_RS05050 964559..965200 + 642 WP_001019783.1 hypothetical protein -
EW033_RS05055 965649..965990 + 342 WP_001190616.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 956193..968304 12111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-97)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11590.08 Da        Isoelectric Point: 4.9594

>T286163 WP_001103946.1 NZ_LR130515:960888-961181 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA

Download         Length: 294 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8238.28 Da        Isoelectric Point: 4.3718

>AT286163 WP_001058492.1 NZ_LR130515:960676-960885 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6E6D5

Antitoxin

Source ID Structure
AlphaFold DB X5IA75

References