Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2141749..2142278 Replicon chromosome
Accession NZ_LR130513
Organism Staphylococcus aureus strain BPH2900 isolate BPH2900

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EW029_RS10970 Protein ID WP_000621175.1
Coordinates 2141749..2142111 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EW029_RS10975 Protein ID WP_000948330.1
Coordinates 2142108..2142278 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW029_RS10945 2138727..2139497 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
EW029_RS10950 2139472..2139951 - 480 WP_001190825.1 anti-sigma B factor RsbW -
EW029_RS10955 2139953..2140279 - 327 WP_001052491.1 anti-sigma factor antagonist -
EW029_RS10960 2140399..2141400 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
EW029_RS10970 2141749..2142111 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EW029_RS10975 2142108..2142278 - 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EW029_RS10980 2142363..2143511 - 1149 WP_129654717.1 alanine racemase -
EW029_RS10985 2143577..2143936 - 360 WP_000581193.1 holo-ACP synthase -
EW029_RS10990 2143940..2144431 - 492 WP_001205918.1 PH domain-containing protein -
EW029_RS10995 2144418..2146001 - 1584 WP_001294624.1 PH domain-containing protein -
EW029_RS11000 2145994..2146473 - 480 WP_001287080.1 hypothetical protein -
EW029_RS11005 2146682..2147242 - 561 WP_001092400.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286155 WP_000621175.1 NZ_LR130513:c2142111-2141749 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT286155 WP_000948330.1 NZ_LR130513:c2142278-2142108 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References