Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1926290..1927066 Replicon chromosome
Accession NZ_LR130513
Organism Staphylococcus aureus strain BPH2900 isolate BPH2900

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag EW029_RS09600 Protein ID WP_000031112.1
Coordinates 1926290..1926442 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag EW029_RS09605 Protein ID WP_001251224.1
Coordinates 1926467..1927066 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW029_RS09585 1922196..1923017 + 822 WP_000669382.1 RluA family pseudouridine synthase -
EW029_RS09590 1923479..1924864 - 1386 WP_000116232.1 class II fumarate hydratase -
EW029_RS09595 1925060..1925455 - 396 WP_000901023.1 hypothetical protein -
EW029_RS09600 1926290..1926442 - 153 WP_000031112.1 hypothetical protein Toxin
EW029_RS09605 1926467..1927066 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
EW029_RS09610 1927225..1927695 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EW029_RS09615 1927700..1928827 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
EW029_RS09620 1928977..1929699 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
EW029_RS09625 1929692..1931149 - 1458 WP_000649910.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5966.31 Da        Isoelectric Point: 3.8962

>T286152 WP_000031112.1 NZ_LR130513:c1926442-1926290 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELSKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT286152 WP_001251224.1 NZ_LR130513:c1927066-1926467 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References