286138

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2049064..2049593 Replicon chromosome
Accession NZ_LR130511
Organism Staphylococcus aureus strain BPH2819 isolate BPH2819

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EW030_RS10515 Protein ID WP_000621175.1
Coordinates 2049064..2049426 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag EW030_RS10520 Protein ID WP_000948331.1
Coordinates 2049423..2049593 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW030_RS10490 2046042..2046812 - 771 WP_001041111.1 RNA polymerase sigma factor SigB -
EW030_RS10495 2046787..2047266 - 480 WP_001190829.1 anti-sigma B factor RsbW -
EW030_RS10500 2047268..2047594 - 327 WP_001052491.1 anti-sigma factor antagonist -
EW030_RS10505 2047713..2048714 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
EW030_RS10515 2049064..2049426 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EW030_RS10520 2049423..2049593 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EW030_RS10525 2049678..2050826 - 1149 WP_001281154.1 alanine racemase -
EW030_RS10530 2050892..2051251 - 360 WP_000581197.1 holo-ACP synthase -
EW030_RS10535 2051255..2051746 - 492 WP_001205912.1 PH domain-containing protein -
EW030_RS10540 2051733..2053316 - 1584 WP_001294626.1 PH domain-containing protein -
EW030_RS10545 2053309..2053788 - 480 WP_001287087.1 hypothetical protein -
EW030_RS10550 2053996..2054556 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286138 WP_000621175.1 NZ_LR130511:c2049426-2049064 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT286138 WP_000948331.1 NZ_LR130511:c2049593-2049423 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References