Detailed information of TA system TA028613

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2662130..2662740
• Replicon: chromosome
• Accession: NC_019780
• Organism: Dactylococcopsis salina PCC 8305

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DACSA_RS12985
• Protein ID: WP_015230196.1
• Coordinates: 2662130..2662513 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K9YXJ5
• Locus tag: DACSA_RS12990
• Protein ID: WP_015230197.1
• Coordinates: 2662510..2662740 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DACSA_RS12960	2657750..2658067	-	318	WP_015230191.1	HigA family addiction module antidote protein	-
DACSA_RS12965	2658213..2658908	-	696	WP_015230192.1	ribulose-phosphate 3-epimerase	-
DACSA_RS12970	2658993..2660585	+	1593	WP_015230193.1	S8 family serine peptidase	-
DACSA_RS12975	2660552..2661346	-	795	WP_015230194.1	SWIM zinc finger family protein	-
DACSA_RS12980	2661455..2662039	-	585	WP_198007738.1	Uma2 family endonuclease	-
DACSA_RS12985	2662130..2662513	-	384	WP_015230196.1	type II toxin-antitoxin system VapC family toxin	Toxin
DACSA_RS12990	2662510..2662740	-	231	WP_015230197.1	DUF2281 domain-containing protein	Antitoxin
DACSA_RS12995	2662928..2664607	-	1680	WP_015230198.1	chaperonin GroEL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (5-127)

Antitoxin

• Domain of unknown function DUF2281 (6-74)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14795.11 Da
• Isoelectric Point: 5.5160

>T28613 WP_015230196.1 NC_019780:c2662513-2662130 [Dactylococcopsis salina PCC 8305]
MSAFLLDTHAFIWLSEDDPNLPDFLRERIDQADFVYVSIASLWEIAIKLNLGKLSLKQNYEIIGIELGYSDIIVLPISFR
DTALIRHLPLHHRDPFDRMLIAQAMNHSLIVVSRDRAFDAYSIQRIW

Nucleotide

• Length: 384 bp

>T28613 NC_019780:c2662513-2662130 [Dactylococcopsis salina PCC 8305]
ATGAGTGCTTTTCTCTTAGACACTCATGCTTTTATTTGGTTGTCGGAAGATGACCCAAACTTACCAGACTTTCTCAGAGA
GAGGATTGATCAAGCTGATTTTGTATATGTTAGCATTGCAAGTCTATGGGAGATTGCAATTAAGTTAAACCTTGGCAAAT
TATCTCTAAAACAAAATTATGAAATCATTGGCATTGAGCTTGGATATTCTGACATTATTGTACTTCCTATTTCCTTTCGC
GATACAGCTTTGATTCGCCACTTACCTTTACATCATCGAGACCCATTTGATCGAATGTTAATTGCACAAGCAATGAATCA
TTCTTTAATTGTAGTCAGTCGCGATCGCGCCTTTGATGCTTATTCAATACAAAGAATTTGGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8948.12 Da
• Isoelectric Point: 4.4475

>AT28613 WP_015230197.1 NC_019780:c2662740-2662510 [Dactylococcopsis salina PCC 8305]
MNTDLQLWQTISKMPEHLKTELLNYAEYLMEKKANTTHSDQNLEKKQRSGVLKGTFVLPLPEDFDEPLEGFQDYME

Nucleotide

• Length: 231 bp

>AT28613 NC_019780:c2662740-2662510 [Dactylococcopsis salina PCC 8305]
ATGAATACTGATCTCCAACTCTGGCAAACCATTAGCAAAATGCCTGAACATTTAAAGACTGAATTGCTAAATTATGCGGA
ATATTTAATGGAGAAAAAAGCAAACACAACTCACTCGGATCAAAACTTAGAAAAAAAACAGCGATCGGGGGTTTTGAAAG
GAACTTTTGTCTTACCATTACCAGAAGACTTTGATGAACCATTAGAAGGTTTTCAGGATTATATGGAATGA

Structures

Antitoxin

• AlphaFold DB: K9YXJ5