Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2039800..2040329 Replicon chromosome
Accession NZ_LR130509
Organism Staphylococcus aureus strain BPH2760 isolate BPH2760

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EW032_RS10400 Protein ID WP_000621175.1
Coordinates 2039800..2040162 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag EW032_RS10405 Protein ID WP_000948331.1
Coordinates 2040159..2040329 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW032_RS10375 2036778..2037548 - 771 WP_001041108.1 RNA polymerase sigma factor SigB -
EW032_RS10380 2037523..2038002 - 480 WP_001190830.1 anti-sigma B factor RsbW -
EW032_RS10385 2038004..2038330 - 327 WP_001052491.1 anti-sigma factor antagonist -
EW032_RS10390 2038449..2039450 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
EW032_RS10400 2039800..2040162 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EW032_RS10405 2040159..2040329 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EW032_RS10410 2040414..2041562 - 1149 WP_001281154.1 alanine racemase -
EW032_RS10415 2041628..2041987 - 360 WP_000581197.1 holo-ACP synthase -
EW032_RS10420 2041991..2042482 - 492 WP_001205912.1 PH domain-containing protein -
EW032_RS10425 2042469..2044052 - 1584 WP_063456354.1 PH domain-containing protein -
EW032_RS10430 2044045..2044524 - 480 WP_001287078.1 hypothetical protein -
EW032_RS10435 2044733..2045293 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286126 WP_000621175.1 NZ_LR130509:c2040162-2039800 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT286126 WP_000948331.1 NZ_LR130509:c2040329-2040159 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References