Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1883129..1883905 Replicon chromosome
Accession NZ_LR130509
Organism Staphylococcus aureus strain BPH2760 isolate BPH2760

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag EW032_RS09450 Protein ID WP_000031108.1
Coordinates 1883129..1883281 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag EW032_RS09455 Protein ID WP_001251224.1
Coordinates 1883306..1883905 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW032_RS09430 1879265..1880086 + 822 WP_000669376.1 RluA family pseudouridine synthase -
EW032_RS09435 1880547..1881932 - 1386 WP_000116229.1 class II fumarate hydratase -
EW032_RS09440 1882128..1882523 - 396 WP_000901023.1 hypothetical protein -
EW032_RS09450 1883129..1883281 - 153 WP_000031108.1 hypothetical protein Toxin
EW032_RS09455 1883306..1883905 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
EW032_RS09460 1884064..1884534 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EW032_RS09465 1884539..1885666 - 1128 WP_000379987.1 tRNA epoxyqueuosine(34) reductase QueG -
EW032_RS09470 1885817..1886539 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
EW032_RS09475 1886532..1887989 - 1458 WP_129621264.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T286125 WP_000031108.1 NZ_LR130509:c1883281-1883129 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT286125 WP_001251224.1 NZ_LR130509:c1883905-1883306 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References